As the Ebola virus outbreak continues to run amok in West Africa, scientists are looking ahead to the possibly pivotal use of experimental drugs and vaccines against the disease. It will take months to test, produce and deploy the therapies. But researchers hold out hope that these products — even incompletely vetted — might help to turn the tide against an illness that has defied public health efforts to bring it under control.

Black Hole

A black hole is a region of spacetime from which nothing, not even light, can escape. The theory of general relativity predicts that a sufficiently compact mass will deform spacetime to form a black hole. Around a black hole there is a mathematically defined surface called an event horizon that marks the point of no return. It is called "black" because it absorbs all the light that hits the horizon, reflecting nothing, just like a perfect black body in thermodynamics. Quantum mechanics predicts that black holes emit radiation like a black body with a finite temperature. This temperature is inversely proportional to the mass of the black hole, making it difficult to observe this radiation for black holes of stellar mass or greater.
Objects whose gravity field is too strong for light to escape were first considered in the 18th century by John Michell and Pierre-Simon Laplace. The first modern solution of general relativity containing a black hole was found by Karl Schwarzschild in 1916, although its interpretation as a region of space from which nothing can escape was not fully appreciated for another four decades. Long considered a mathematical curiosity, it was during the 1960s that theoretical work showed black holes were a generic prediction of general relativity. The discovery of neutron stars sparked interest in gravitationally collapsed compact objects as a possible astrophysical reality.
Black holes of stellar mass are expected to form when heavy stars collapse in a supernova at the end of their life cycle. After a black hole has formed it can continue to grow by absorbing mass from its surroundings. By absorbing other stars and merging with other black holes, supermassive black holes of millions of solar masses may be formed.
Despite its invisible interior, the presence of a black hole can be inferred through its interaction with other matter. Astronomers have identified numerous stellar black hole candidates in binary systems, by studying their interaction with their companion stars. There is growing consensus that supermassive black holes exist in the centers of most galaxies. In particular, there is strong evidence of a black hole of more than 4 million solar masses at the center of our Milky Way.

History

Schwarzschild black hole
The idea of a body so massive that even light could not escape was first put forward by geologist John Michell in a letter written to Henry Cavendish in 1783 of the Royal Society:
If the semi-diameter of a sphere of the same density as the Sun were to exceed that of the Sun in the proportion of 500 to 1, a body falling from an infinite height towards it would have acquired at its surface greater velocity than that of light, and consequently supposing light to be attracted by the same force in proportion to its vis inertiae, with other bodies, all light emitted from such a body would be made to return towards it by its own proper gravity.
—John Michell
In 1796, mathematician Pierre-Simon Laplace promoted the same idea in the first and second editions of his book Exposition du système du Monde (it was removed from later editions). Such "dark stars" were largely ignored in the nineteenth century, since it was not understood how a massless wave such as light could be influenced by gravity.

General relativity

In 1915, Albert Einstein developed his theory of general relativity, having earlier shown that gravity does influence light's motion. Only a few months later, Karl Schwarzschild found a solution to Einstein field equations, which describes the gravitational field of a point mass and a spherical mass.A few months after Schwarzschild, Johannes Droste, a student of Hendrik Lorentz, independently gave the same solution for the point mass and wrote more extensively about its properties.This solution had a peculiar behaviour at what is now called the Schwarzschild radius, where it became singular, meaning that some of the terms in the Einstein equations became infinite. The nature of this surface was not quite understood at the time. In 1924, Arthur Eddington showed that the singularity disappeared after a change of coordinates (see Eddington–Finkelstein coordinates), although it took until 1933 for Georges Lemaître to realize that this meant the singularity at the Schwarzschild radius was an unphysical coordinate singularity.
In 1931, Subrahmanyan Chandrasekhar calculated, using general relativity, that a non-rotating body of electron-degenerate matter above a certain limiting mass (now called the Chandrasekhar limit at 1.4 solar masses) must have an infinite density. In other words, the object must have a radius of zero. His arguments were opposed by many of his contemporaries like Eddington and Lev Landau, who argued that some yet unknown mechanism would stop the collapse. They were partly correct: a white dwarf slightly more massive than the Chandrasekhar limit will collapse into a neutron star, which is itself stable because of the Pauli exclusion principle. But in 1939, Robert Oppenheimer and others predicted that neutron stars above approximately three solar masses (the Tolman–Oppenheimer–Volkoff limit) would collapse into black holes for the reasons presented by Chandrasekhar, and concluded that no law of physics was likely to intervene and stop at least some stars from collapsing to black holes.
Oppenheimer and his co-authors interpreted the singularity at the boundary of the Schwarzschild radius as indicating that this was the boundary of a bubble in which time stopped. This is a valid point of view for external observers, but not for infalling observers. Because of this property, the collapsed stars were called "frozen stars," because an outside observer would see the surface of the star frozen in time at the instant where its collapse takes it inside the Schwarzschild radius.